Chiarelli F, Verrotti A, Kalter-Leibovici O, Laron Z, Morgese G
University Department of Pediatrics, Chieti, Italy.
J Paediatr Child Health. 1994 Dec;30(6):547-9. doi: 10.1111/j.1440-1754.1994.tb00732.x.
In order to evaluate whether insulin-dependent diabetes mellitus patients with incipient nephropathy have an overactivity of erythrocyte sodium-lithium countertransport (Na+/Li+ CT), 82 diabetic children and 38 healthy age-matched control subjects and their parents and grandparents were studied. The children were divided into two groups according to the presence of persistent microalbuminuria (MA). Diabetic children with MA had Na+/Li+ CT activity higher than normoalbuminuric diabetics and healthy controls. The parents and grandparents of microalbuminuric patients showed higher Na+/Li+ CT than parents and grandparents of normoalbuminuric diabetics and of the controls. This study demonstrates that predisposition to hypertension, as indicated by increased Na+/Li+ CT activity in erythrocytes, is more frequently detectable in patients with persistent microalbuminuria than in diabetics without persistent microalbuminuria or in healthy controls. Overactivity of Na+/Li+ CT is present also in parents and grandparents of diabetic children with MA. This study suggests that genetic predisposition to hypertension is more frequent in patients at risk of developing diabetic nephropathy, as well as in their parents and grandparents.
为了评估胰岛素依赖型糖尿病初发肾病患者是否存在红细胞钠-锂逆向转运（Na⁺/Li⁺ CT）活性亢进，对82例糖尿病儿童以及38例年龄匹配的健康对照受试者及其父母和祖父母进行了研究。根据持续性微量白蛋白尿（MA）的有无将儿童分为两组。有MA的糖尿病儿童的Na⁺/Li⁺ CT活性高于正常白蛋白尿的糖尿病患者和健康对照。微量白蛋白尿患者的父母和祖父母的Na⁺/Li⁺ CT高于正常白蛋白尿糖尿病患者和对照的父母和祖父母。本研究表明，红细胞中Na⁺/Li⁺ CT活性增加所提示的高血压易感性，在持续性微量白蛋白尿患者中比在无持续性微量白蛋白尿的糖尿病患者或健康对照中更常见。有MA的糖尿病儿童的父母和祖父母也存在Na⁺/Li⁺ CT活性亢进。本研究提示，高血压的遗传易感性在有发生糖尿病肾病风险的患者及其父母和祖父母中更为常见。
