Champ C, Byard R W
Department of Histopathology, Adelaide Children's Hospital, Australia.
J Paediatr Child Health. 1994 Dec;30(6):550-1. doi: 10.1111/j.1440-1754.1994.tb00733.x.
Review of the Department of Histopathology autopsy files over a 30 year period from 1962 to 1991 revealed only three cases in which unexpected death occurred in infants under 1 year of age due to massive pulmonary thromboemboli. Predisposing factors included necrotizing enterocolitis with gut perforation and sepsis, a ventriculoatrial shunt and idiopathic arterial calcification. Diagnosis of the latter autosomal recessive condition was only made at autopsy. These cases demonstrate that pulmonary thromboembolism is a possible, although exceedingly rare, cause of sudden infant death, that some predisposing factors are unique to infancy and that the source of the pulmonary thromboembolus may be difficult to determine at autopsy. Massive pulmonary thromboembolism in infancy may point to the presence of other significant, clinically-unsuspected, disorders.
对1962年至1991年这30年间组织病理学部门尸检档案的回顾显示，仅有3例1岁以下婴儿因大量肺血栓栓塞意外死亡。诱发因素包括伴有肠道穿孔和败血症的坏死性小肠结肠炎、脑室心房分流术和特发性动脉钙化。后者这种常染色体隐性疾病仅在尸检时得以诊断。这些病例表明，肺血栓栓塞是婴儿猝死的一种可能原因，尽管极为罕见，一些诱发因素是婴儿期所特有的，而且肺血栓栓子的来源在尸检时可能难以确定。婴儿期大量肺血栓栓塞可能提示存在其他重要的、临床上未被怀疑的疾病。
