单相患者中NAG水平与特定精神症状的关联。

Association of NAG levels with specific psychiatric symptoms in unipolar patients.

作者信息

Garvey M J, Noel M

机构信息

Department of Psychiatry, University of Iowa College of Medicine, Iowa City.

出版信息

J Psychiatry Neurosci. 1995 Jan;20(1):20-4.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1188654/

Abstract

The levels of N-acetyl-beta-glucosaminidase (NAG) from 57 unipolar patients were compared to the scores of symptom severity for nine symptom clusters derived from the Symptom Check List (SCL-90). The depression and hostility clusters were significantly associated with NAG levels. In a separate study of 21 unipolar patients, six out of 31 mood symptoms were significantly associated with NAG levels, as were two out of seven tested RDC depression subtypes. Serotonin abnormalities may play a role in the production of many of these symptoms. A hypothesis that NAG could be a marker for serotonin activity is discussed.

摘要

将57名单相情感障碍患者的N-乙酰-β-氨基葡萄糖苷酶（NAG）水平与从症状自评量表（SCL-90）得出的九个症状群的症状严重程度评分进行了比较。抑郁和敌对症状群与NAG水平显著相关。在另一项对21名单相情感障碍患者的研究中，31种情绪症状中的6种与NAG水平显著相关，7种经测试的研究诊断标准（RDC）抑郁亚型中的2种也与NAG水平显著相关。血清素异常可能在许多这些症状的产生中起作用。本文讨论了NAG可能是血清素活性标志物的假说。

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