Pillai M R, John C S, Lo J M, Troutner D E, Corlija M, Volkert W A, Holmes R A
Isotope Division, Bhabha Atomic Research Center, Bombay, India.
J Nucl Biol Med (1991). 1994 Sep;38(3):527-31.
Synthesis and characterization of a new pentadentate amine-oxime ligand, 3,3,11,11-tetramethyl-7-benzyl-4,7,10-triazatridecane-2,12- dionedioxime is reported. The technetium complexes of this ligand was formed by direct reduction of TcO4- in the presence of the ligand at pH 9. The radiochemical yield of the complex is greater than 95% with 10(-7) M 99TcO4-. The technetium complex formed is a positively charged chelate that elutes as a single peak on a reverse phase HPLC. Biodistribution studies in rats showed an uptake of 1.4% of the injected activity at 15 sec p.i. in heart, but the wash-out was fast. The high radiochemical purity and stability of this 99mTc-chelate indicate that these types of chelates hold potential for development of bifunctional chelating agents (BFCAs).
报道了一种新型五齿胺肟配体3,3,11,11-四甲基-7-苄基-4,7,10-三氮杂十三烷-2,12-二酮二肟的合成与表征。该配体的锝配合物是在pH 9的条件下，于配体存在时通过直接还原高锝酸根形成的。对于10(-7) M的99TcO4-，配合物的放射化学产率大于95%。所形成的锝配合物是一种带正电荷的螯合物，在反相高效液相色谱上以单峰形式洗脱。在大鼠体内的生物分布研究表明，注射后15秒时心脏对注入活性的摄取为1.4%，但清除速度很快。这种99mTc-螯合物的高放射化学纯度和稳定性表明，这类螯合物在双功能螯合剂（BFCAs）的开发方面具有潜力。
