[IgA和IgM型血清学反应在急性弓形虫病诊断中的比较研究]

[Comparative study of the serologic response of IgA and IgM type in the diagnosis of acute toxoplasmosis].

作者信息

Lafarga B, Cañas A, Pérez M C, Suárez J, Elcuaz R

机构信息

Servicio de Microbiología, Hospital Nuestra Señora del Pino, Las Palmas de Gran Canaria.

出版信息

Enferm Infecc Microbiol Clin. 1994 Dec;12(10):501-4.

Abstract

BACKGROUND

IgM serologic response in the diagnosis of acute toxoplasmosis presents interpretation problems. A comparative study with IgA detection of antibodies was performed.

METHODS

A parallel serologic study was carried out with IgM and IgA enzymoimmunoassay enhancement techniques in the sera of patients suspected of having toxoplasmosis.

RESULTS

Positive results for IgM and/or IgA were presented in 74 sera (47 patients): 86.3% for the former and 58.9% for the latter (p < 0.001). The group of IgA-/IgA+ sera presented a low mean of proportionality index (PI): 1.6 versus the IgM+ sera group in the context of IgG seroconversion with a PI of 3.4 (p < 0.001). Out of the 9 patients with demonstrated IgG, all were IgA+ and seven IgM+.

CONCLUSIONS

The present data seem to support greater specificity of the determination of IgA antibodies than that of IgM in the diagnosis of acute toxoplasmosis.

摘要

背景

IgM血清学反应在急性弓形虫病诊断中存在解读问题。开展了一项与IgA抗体检测的对比研究。

方法

采用IgM和IgA酶免疫分析增强技术，对疑似弓形虫病患者的血清进行平行血清学研究。

结果

74份血清（47例患者）中IgM和/或IgA呈阳性结果：前者为86.3%，后者为58.9%（p<0.001）。在IgG血清转换情况下，IgA - /IgA +血清组的比例指数（PI）均值较低：为1.6，而IgM +血清组的PI为3.4（p<0.001）。在9例IgG得到证实的患者中，全部为IgA +，7例为IgM +。

结论

目前的数据似乎支持在急性弓形虫病诊断中，IgA抗体检测比IgM检测具有更高的特异性。