Andrés S, Jiménez A, Sánchez J, Mañé C, Barrera R, Rodríguez J
Departamento de Medicina y Sanidad Animal, Facultad de Veterinaria, Cáceres, Spain.
Eur J Clin Chem Clin Biochem. 1994 Sep;32(9):719-21.
The influence of lithium heparin and heparin iodoacetate on the determination of blood glutathione peroxidase activity was investigated. Samples with each anticoagulant were taken from 393 lambs. Glutathione peroxidase activity was much higher in the lithium heparin samples (109.00 +/- 3.71 U/g Hb) than in the heparin iodoacetate group (31.05 +/- 1.55 U/g Hb). This difference was statistically significant (p < 0.001), and it was due to inhibition of glutathione peroxidase by heparin iodoacetate. Heparin iodoacetate therefore cannot be used as an anticoagulant in the determination of glutathione peroxidase in blood.
研究了肝素锂和碘乙酸肝素对血液谷胱甘肽过氧化物酶活性测定的影响。从393只羔羊采集了使用每种抗凝剂的样本。肝素锂样本中的谷胱甘肽过氧化物酶活性（109.00±3.71 U/g Hb）比碘乙酸肝素组（31.05±1.55 U/g Hb）高得多。这种差异具有统计学意义（p<0.001），这是由于碘乙酸肝素对谷胱甘肽过氧化物酶的抑制作用所致。因此，碘乙酸肝素不能用作测定血液中谷胱甘肽过氧化物酶时的抗凝剂。
