与胸膜脂肪肉瘤相关的获得性凝血因子VII缺乏症。
Acquired factor VII deficiency associated with pleural liposarcoma.
作者信息
de Raucourt E, Dumont M D, Tourani J M, Hubsch J P, Riquet M, Fischer A M
机构信息
Department of Haematology, Hôpital Laennec, Paris, France.
出版信息
Blood Coagul Fibrinolysis. 1994 Oct;5(5):833-6. doi: 10.1097/00001721-199410000-00023.
Isolated acquired factor VII (FVII) deficiency (0.15 U/ml) was identified in a 30-year-old man with pleural liposarcoma. The patient underwent surgery with continuous FVII concentrate infusion. No anti-FVII antibody or FVII/anti-FVII complex was detected. However, the short half-life and low recovery of FVII after concentrate infusion suggested the presence of an antibody. Whatever the mechanism, this FVII deficiency was related to the presence of the liposarcoma. FVII level normalized during tumour regression and fell again when the liposarcoma relapsed.
在一名患有胸膜脂肪肉瘤的30岁男性中发现了孤立性获得性凝血因子VII（FVII）缺乏（0.15 U/ml）。该患者在持续输注FVII浓缩物的情况下接受了手术。未检测到抗FVII抗体或FVII/抗FVII复合物。然而，浓缩物输注后FVII的半衰期短且回收率低提示存在抗体。无论机制如何，这种FVII缺乏与脂肪肉瘤的存在有关。在肿瘤消退期间FVII水平恢复正常，而当脂肪肉瘤复发时FVII水平再次下降。
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