Virgili M, Facchinetti F, Contestabile A
Department of Biology, University of Bologna, Italy.
Neuroreport. 1994 Oct 27;5(16):2023-5. doi: 10.1097/00001756-199410270-00008.
Rat pups were treated daily with increasing doses of the competitive N-methyl-D-aspartate (NMDA) antagonist CGP 39551 from postnatal day 1 to 22. Normal rats, as well as rats kept undernourished to the same extent as CGP 39551-treated animals were raised in parallel. The neonatal treatment resulted in significant increase of choline acetyltransferase (+14%) in the adult spinal cord. High affinity glutamate uptake was increased to a similar magnitude in treated rats, but the same effect was also noticed for neonatally undernourished rats. No alteration of other neurochemical markers was observed. The present results add new evidence to a developmental role mediated by NMDA receptors and extend to the spinal cord the value of models of chronic neonatal block of this receptor.
从出生后第1天至22天，每天用递增剂量的竞争性N-甲基-D-天冬氨酸（NMDA）拮抗剂CGP 39551处理新生大鼠。正常大鼠以及与CGP 39551处理组动物营养不良程度相同的大鼠平行饲养。新生期处理导致成年脊髓中胆碱乙酰转移酶显著增加（增加14%）。在处理过的大鼠中，高亲和力谷氨酸摄取也增加到类似程度，但新生期营养不良的大鼠也观察到同样的效果。未观察到其他神经化学标志物的改变。本研究结果为NMDA受体介导的发育作用增添了新证据，并将该受体慢性新生期阻断模型的价值扩展到脊髓。
