Lewczuk J, Piszko P, Jagas J, Porada A, Sobkowicz-Woźniak B, Wrabec K
Oddziału Internistyczno-Kardiologicznego Wojewódzkiego Szpitala Specjalistycznego we Wrocławiu.
Pneumonol Alergol Pol. 1994;62(9-10):496-500.
It is suggested that ventricular arrhythmias may be the reason of sudden death in stable patients with COPD. Strenuous effort might provoke danger ventricular arrhythmias in those patients. The impact of maximal exercise test on cardiac ventricular arrhythmias was studied in 24 patients with advanced chronic obstructive pulmonary disease (COPD). The treadmill, self limited exercise test according to Bruce protocol and accompanied by pulse oximetry was performed during 24 hour Holter monitoring. We found ventricular extrasystoles in all patients, in an average 492 +/- 770, complex ventricular extrasystoles in 17 patients and nonsustained ventricular tachycardia in 8 patients. 81% of all ventricular extrasystoles, 80% complex ventricular extrasystoles and 70% nonsustained ventricular tachycardia occurred during the test and up to 2 hour after the test. Patients with complex ventricular arrhythmias were younger and mostly achieved more MET during exercise, but they did not differ in advancing of COPD as measured by spirometry, gas measurements and echocardiography. Although maximal exercise test enhances ventricular arrhythmias it produced no sustained, symptomatic ventricular arrhythmias in patients with advanced and stable COPD.
有人认为室性心律失常可能是稳定期慢性阻塞性肺疾病(COPD)患者猝死的原因。剧烈运动可能会诱发这些患者出现危险的室性心律失常。我们对24例晚期慢性阻塞性肺疾病(COPD)患者进行了最大运动试验对心室心律失常影响的研究。在24小时动态心电图监测期间,按照布鲁斯方案进行了平板运动试验,这是一种自我限制的运动试验,并伴有脉搏血氧饱和度监测。我们发现所有患者均出现室性期前收缩,平均为492±770次,17例患者出现复杂性室性期前收缩,8例患者出现非持续性室性心动过速。所有室性期前收缩的81%、复杂性室性期前收缩的80%和非持续性室性心动过速的70%发生在试验期间及试验后2小时内。伴有复杂性室性心律失常的患者较年轻,运动期间大多能达到更多的代谢当量,但通过肺活量测定、气体测量和超声心动图测量,他们在COPD进展方面并无差异。虽然最大运动试验会增加室性心律失常的发生,但在晚期稳定期COPD患者中并未诱发持续性有症状的室性心律失常。