Wolf G K
Eur J Clin Pharmacol. 1976 Mar 22;09(5-6):387-92. doi: 10.1007/BF00606553.
The effect of Arwin on peripheral arterial occlusive disease has been studied in two multicentre trials. In the first, in cases of severe peripheral arterial circulatory disorders of the lower extremities with permanent rest pain (stages III and III + IV according to Fontaine) Arwin had a better intravenous therapeutic effect than anticoagulant treatment. A further trial was done to investigate whether subcutaneous administration of Arwin would have an effect superior to classical conservative therapy with vasodilator drugs in this type of disease. The results were assessed by sequential analysis. Arwin was again shown to be a much better treatment. Problems of medical documentation and statistics are discussed in relation to the value of sequential analysis.
已在两项多中心试验中研究了阿尔文（Arwin）对周围动脉闭塞性疾病的疗效。在第一项试验中，对于患有严重下肢周围动脉循环障碍且伴有持续性静息痛（根据方丹分类为III期和III + IV期）的病例，阿尔文的静脉治疗效果优于抗凝治疗。还进行了另一项试验，以研究皮下注射阿尔文在这类疾病中是否具有优于使用血管扩张剂的传统保守疗法的效果。通过序贯分析对结果进行评估。结果再次表明阿尔文是一种更好的治疗方法。结合序贯分析的价值讨论了医学记录和统计学方面的问题。
