Sivron T, Schwartz M
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Exp Neurol. 1994 Dec;130(2):411-3. doi: 10.1006/exnr.1994.1221.
Fish optic nerve sections were recently shown to be nonpermissive to growth of adult retinal axons. In addition, fish optic nerve myelin was found to inhibit growth of adult retinal axons and this inhibition was neutralized by IN-1 antibodies (known to block rat myelin-associated inhibitors). In this study we examined whether the growth nonpermissiveness of fish optic nerves which had not been injured prior to their excision results, at least in part, from the presence of myelin-associated growth inhibitors. It was found that preincubation of the sections with IN-1 antibodies, known to recognize and neutralize the myelin-associated growth inhibitors of the rat central nervous system, increases sixfold the number of axons that grow on these sections. This demonstrates that fish myelin-associated growth inhibitors, which are similar to those of rat, are at least partly responsible for the growth nonpermissiveness of normal fish optic nerves.
最近研究表明，鱼类视神经切片对成年视网膜轴突的生长不具有促进作用。此外，还发现鱼类视神经髓磷脂会抑制成年视网膜轴突的生长，而这种抑制作用可被IN-1抗体（已知可阻断大鼠髓磷脂相关抑制因子）中和。在本研究中，我们检测了在切除前未受损伤的鱼类视神经生长不具有促进作用是否至少部分是由于髓磷脂相关生长抑制因子的存在。结果发现，用已知可识别并中和大鼠中枢神经系统髓磷脂相关生长抑制因子的IN-1抗体对切片进行预孵育后，在这些切片上生长的轴突数量增加了六倍。这表明，与大鼠相似的鱼类髓磷脂相关生长抑制因子至少部分导致了正常鱼类视神经生长不具有促进作用。
