Baltadzhiev G
Department of Anatomy, University of Medicine, Plovdiv, Bulgaria.
Folia Med (Plovdiv). 1994;36(1):21-8.
Electron microscopic study of the Haversian canal and its content was performed. Four types of wall lining cells were identified: undifferentiated lining cells, resting mature osteoblasts, active osteoblasts, osteoblast-osteocytes which represented different stages in the differentiation process of the fibrilogenetic cell population. The narrow space between the lining cells and the mineralized bone tissue contained randomly oriented collagen fibrils arranged in layers. Such arrangement of the fibrils determined the lamellar model of the osteons prior to their mineralization. The perivascular space contained both poorly differentiated and mature fibrilogenetic cells with numerous cytoplasmic processes as well as collagen fibrils with different orientation. The cells and the fibrils formed networks which were the sites of the metabolic exchange between the blood vessels and the bone tissue. This process was realised in the medium of the interstitial fluid which filled the perivascular space. All these make the perivascular space an important link of the osteon microcirculation.
对哈弗斯管及其内容物进行了电子显微镜研究。鉴定出四种类型的管壁衬里细胞：未分化的衬里细胞、静止的成熟成骨细胞、活跃的成骨细胞、成骨细胞-骨细胞，它们代表了纤维生成细胞群体分化过程中的不同阶段。衬里细胞与矿化骨组织之间的狭窄间隙包含随机排列成层的胶原纤维。这种纤维排列决定了骨单位矿化前的板层模型。血管周围间隙包含分化程度低和成熟的纤维生成细胞，它们具有许多细胞质突起，以及不同取向的胶原纤维。细胞和纤维形成网络，这些网络是血管与骨组织之间代谢交换的场所。这个过程在充满血管周围间隙的组织液介质中实现。所有这些使血管周围间隙成为骨单位微循环的重要环节。
