Sasse F, Steinmetz H, Höfle G, Reichenbach H
GBF, Gesellschaft für Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie, Braunschweig, Germany.
J Antibiot (Tokyo). 1995 Jan;48(1):21-5. doi: 10.7164/antibiotics.48.21.
A new antibiotic compound, gephyronic acid was isolated from the culture broth of the myxobacterium, Archangium gephyra strain Ar 3895. Up to 3 mg/liter was produced during the logarithmic and stationary growth phase. The compound is an aliphatic acid, which tends to form a hemiacetal. Both forms inhibited growth of yeasts and molds (MIC 1-25 micrograms/ml) and had a cytostatic effect on mammalian cell cultures (IC50 10-60 ng/ml). Gephyronic acid is a specific inhibitor of eukaryotic protein synthesis showing an IC50 of 1-2 x 10(-7) mol/liter in an in vitro translation assay.
一种新的抗生素化合物——地衣形酸，是从粘细菌地衣形囊菌Ar 3895菌株的培养液中分离出来的。在对数生长期和稳定期，其产量可达3毫克/升。该化合物是一种脂肪酸，易于形成半缩醛。两种形式均能抑制酵母和霉菌的生长（最低抑菌浓度为1-25微克/毫升），并对哺乳动物细胞培养物具有细胞抑制作用（半数抑制浓度为10-60纳克/毫升）。地衣形酸是真核蛋白质合成的特异性抑制剂，在体外翻译试验中，其半数抑制浓度为1-2×10⁻⁷摩尔/升。
