Kapasi A, Varthakavi P K, Khopkar U, Wadhwa S L, Nihalani K D
Department of Dermatology, TN Medical College & B Y L Nair Charitable Hospital, Bombay.
J Assoc Physicians India. 1994 Jul;42(7):529-30.
Six women (age range 17-38 years), who presented to the dermatology services with biopsy-proven acanthosis nigricans of variable duration were evaluated to rule out endocrine diseases. Menstrual abnormalities (5/6 patients), pallid striae (4/6 patients), hirsutism (4/6 patients) and acne vulgaris (2/6 patients) were found on physical examination. All the patients had body mass indices in the obese (> 27 kg/m2) range, and in association we found ovarian hyperthecosis, PCOD, premature ovarian failure, glucose intolerance and hyperprolactinaemia in the above six patients. The importance of appropriate endocrinal evaluation in patients with biopsy-proven acanthosis nigricans is emphasized.
六名女性（年龄范围17 - 38岁）因活检证实患有不同病程的黑棘皮病而就诊于皮肤科，对其进行评估以排除内分泌疾病。体格检查发现月经异常（5/6患者）、白色条纹（4/6患者）、多毛症（4/6患者）和寻常痤疮（2/6患者）。所有患者的体重指数均处于肥胖范围（> 27 kg/m²），并且我们在上述六名患者中发现了卵巢泡膜细胞增生症、多囊卵巢综合征、卵巢早衰、糖耐量异常和高泌乳素血症。强调了对活检证实患有黑棘皮病的患者进行适当内分泌评估的重要性。
