Wu Q, Wang Q, Taylor K G, Doyle R J
Department of Microbiology and Immunology, University of Louisville, Kentucky 40292.
J Bacteriol. 1995 Mar;177(5):1399-401. doi: 10.1128/jb.177.5.1399-1401.1995.
Several antibiotics, at subinhibitory concentrations, caused an increase in the ability of Streptococcus sobrinus to bind alpha-1,6-glucans, whereas other antibiotics decreased glucan binding. In every case, glucan binding was inversely proportional to cell surface hydrophobicity. High levels of glucan-binding activity resulted in low levels of hydrophobicity, whereas low levels of glucan binding caused high levels of cellular hydrophobicity. The results show that low concentrations of antibiotics may modulate lectin and hydrophobin adhesins in streptococci.
几种抗生素在亚抑菌浓度下,会使远缘链球菌结合α-1,6-葡聚糖的能力增强,而其他抗生素则会降低葡聚糖结合能力。在每种情况下,葡聚糖结合与细胞表面疏水性呈负相关。高水平的葡聚糖结合活性导致低水平的疏水性,而低水平的葡聚糖结合则导致高水平的细胞疏水性。结果表明,低浓度抗生素可能会调节链球菌中的凝集素和疏水蛋白黏附素。