Veiga A, Santaló J, Vidal F, Calderón G, Giménez C, Boada M, Egozcue J, Barri P N
Departamento de Obstetricia y Ginecología, Institut Universitari Dexeus, Barcelona, Spain.
Hum Reprod. 1994 Nov;9(11):2156-9. doi: 10.1093/oxfordjournals.humrep.a138409.
A twin female pregnancy was obtained in a haemophilia carrier after two preimplantation diagnosis cycles. The embryonic sex of biopsied blastomeres was determined with the use of dual fluorescence in-situ hybridization with directly labelled DNA probes specific for the X and Y chromosome. A twin female pregnancy was confirmed by means of ultrasonography and amniocentesis at the 14th week of amenorrhoea. The patient delivered two healthy females by Caesarian section at the 37th week of pregnancy.
一名血友病携带者在经过两个植入前诊断周期后成功怀上了双胞胎女孩。通过使用针对X和Y染色体的直接标记DNA探针进行双重荧光原位杂交，确定了活检卵裂球的胚胎性别。在闭经第14周时，通过超声检查和羊膜穿刺术确认了双胞胎女孩妊娠。患者在怀孕第37周时通过剖宫产分娩出两名健康女婴。
