Zeballos R S, Fox R I, Cheresh D A, McPherson R A
Scripps Immunology Reference Laboratory, La Jolla, California.
J Clin Lab Anal. 1994;8(6):378-84. doi: 10.1002/jcla.1860080607.
Antibodies directed against ganglioside GM1 or sulfatides are frequently associated with motor or sensorimotor neuropathies. To establish the prevalence of such anti-glycosphingolipid autoantibodies in autoimmune disorders and to determine whether they contribute to neurologic symptoms in those individuals, we measured these antibodies by enzyme-linked immunosorbent assay (ELISA) in serum samples from rheumatologic patients with and without peripheral neuropathies (PN). We tested 21 patients with systemic lupus erythematosus (9 with PN), 26 with Sjögren's syndrome (12 with PN), 34 with scleroderma (28 with PN), and 14 with rheumatoid arthritis (4 with PN). Samples from 32 normal individuals were also tested. Patients with systemic lupus erythematosus and rheumatoid arthritis had elevated concentrations of GM1 antibodies and scleroderma patients had lower levels of sulfatide antibodies compared to healthy individuals. The presence of ganglioside or sulfatide antibodies did not correlate with the development of peripheral neuropathy in these patients. These findings suggest that relatively low-titer glycosphingolipid antibodies may arise as part of a nonspecific polyclonal gammopathy in rheumatologic disorders but generally without clinical manifestation.
针对神经节苷脂GM1或硫脂的抗体常与运动或感觉运动性神经病变相关。为确定此类抗糖鞘脂自身抗体在自身免疫性疾病中的患病率，并确定它们是否会导致这些个体出现神经症状，我们采用酶联免疫吸附测定（ELISA）法检测了有或无周围神经病变（PN）的风湿性疾病患者血清样本中的这些抗体。我们检测了21例系统性红斑狼疮患者（9例有PN）、26例干燥综合征患者（12例有PN）、34例硬皮病患者（28例有PN）和14例类风湿关节炎患者（4例有PN）。还检测了32名正常个体的样本。与健康个体相比，系统性红斑狼疮和类风湿关节炎患者的GM1抗体浓度升高，硬皮病患者的硫脂抗体水平较低。在这些患者中，神经节苷脂或硫脂抗体的存在与周围神经病变的发生无关。这些发现表明，相对低滴度的糖鞘脂抗体可能是风湿性疾病中非特异性多克隆丙种球蛋白病的一部分，但通常无临床表现。
