Fraenkel L, MacKenzie T, Joseph L, Kashgarian M, Hayslett J P, Esdaile J M
Division of Rheumatology, Montreal General Hospital, McGill University, PQ, Canada.
J Rheumatol. 1994 Nov;21(11):2052-7.
To evaluate response to therapy over one year as a predictor of several longterm outcomes in lupus nephritis.
Response to treatment was evaluated by comparing serum creatinine and 24 h urine protein excretion at initial renal biopsy to those obtained after one year of treatment. Response at one year was evaluated as a predictor of renal failure, death due to lupus nephritis, and total lupus mortality, using survival analysis.
Eighty-five patients with lupus nephritis diagnosed between 1967 and 1983 and followed through 1990 were studied. Change in proteinuria was a powerful predictor of renal failure (p = 0.001) death due to lupus nephritis (p < 0.001) and overall lupus mortality (p = 0.001). In contrast to a recent study of patients selected for severe lupus nephritis, serum creatinine was not found to be of prognostic significance.
Response of proteinuria to treatment over one year is a useful predictor of longterm outcomes in lupus nephritis.
评估一年的治疗反应作为狼疮性肾炎几种长期预后指标的情况。
通过比较初始肾活检时的血清肌酐和24小时尿蛋白排泄量与治疗一年后的结果来评估治疗反应。使用生存分析评估一年时的反应作为肾衰竭、狼疮性肾炎死亡和狼疮总死亡率的预测指标。
研究了1967年至1983年间诊断为狼疮性肾炎并随访至1990年的85例患者。蛋白尿的变化是肾衰竭（p = 0.001）、狼疮性肾炎死亡（p < 0.001）和狼疮总死亡率（p = 0.001）的有力预测指标。与最近一项针对重度狼疮性肾炎患者的研究不同，未发现血清肌酐具有预后意义。
蛋白尿对一年治疗的反应是狼疮性肾炎长期预后的有用预测指标。
