对黑猩猩（Pan troglodytes）血液凝固机制激活的研究综述。

A review of studies of the activation of the blood coagulation mechanism in chimpanzees (Pan troglodytes).

作者信息

ten Cate H, Schenk B E, Biemond B J, Levi M, van der Poll T, Buller H R, ten Cate J W

机构信息

Center for Thrombosis, Hemostasis, Atherosclerosis, and Inflammation Research, Academic Medical Center, Amsterdam, The Netherlands.

出版信息

J Med Primatol. 1994 Jul;23(5):280-4. doi: 10.1111/j.1600-0684.1994.tb00285.x.

DOI:10.1111/j.1600-0684.1994.tb00285.x

PMID:7869356

Abstract

This paper reviews our recent studies of blood coagulation activation in the chimpanzee which were carried out employing sensitive immunoassays that measure activation markers of blood coagulation in plasma. Infused factor VIIa activated both factors IX and X in vivo; this reaction depended on the formation of the factor VIIa-tissue factor (TF) complex. The infusion of endotoxin also led to assembly of the factor VIIa-TF complex, enhancing fibrin formation. This process occurred through the intermediate action of specific cytokines.

摘要

本文综述了我们最近对黑猩猩血液凝固激活的研究，这些研究采用了灵敏的免疫测定法来测量血浆中血液凝固的激活标志物。注入的凝血因子VIIa在体内激活了凝血因子IX和X；这种反应依赖于凝血因子VIIa-组织因子（TF）复合物的形成。注入内毒素也导致凝血因子VIIa-TF复合物的组装，增强纤维蛋白的形成。这个过程是通过特定细胞因子的中间作用发生的。