Dittmer U, Lüke W, Stahl-Hennig C, Coulibaly C, Petry H, Bodemer W, Hunsmann G, Voss G
Deutsches Primatenzentrum, Abteilung Virologie und Immunologie, Göttingen, Germany.
J Med Primatol. 1994 Jul;23(5):298-303. doi: 10.1111/j.1600-0684.1994.tb00287.x.
Both naive and vaccinated macaques acquired a virus-specific proliferative helper T-cell reactivity in response to infection with the nonpathogenic human immunodeficiency virus type 2 (HIV-2). In contrast, macaques infected with the pathogenic simian immunodeficiency virus of the macaque strain (SIVmac) did not develop a helper T-cell response. Furthermore, a vaccine-induced preexisting T-cell reactivity was abrogated after SIVmac infection in vaccine failures. These differences may reflect the different pathogenicity of the two closely related viruses.
无论是未接种疫苗的猕猴还是接种过疫苗的猕猴，在感染非致病性人类免疫缺陷病毒2型（HIV-2）后，均获得了病毒特异性增殖辅助性T细胞反应。相比之下，感染致病性猕猴品系猿猴免疫缺陷病毒（SIVmac）的猕猴未产生辅助性T细胞反应。此外，在疫苗接种失败的情况下，SIVmac感染后疫苗诱导的预先存在的T细胞反应被消除。这些差异可能反映了这两种密切相关病毒的不同致病性。
