Dunbar C C, Kalinski M I
Department of Physical Education, Brooklyn College, City University of New York, Brooklyn 11210.
Med Sci Sports Exerc. 1994 Dec;26(12):1459-65.
The effects of acute and chronic exercise on 3'5'-adenosine monophosphate (cAMP) concentration, adenylate cyclase activity, cAMP-phosphodiesterase (PDE), and cAMP-dependent protein kinase (A-kinase) activity are reviewed. During very mild- to moderate-intensity exercise with durations of up to 1 h, the cAMP concentration within the myocardium is related to the intensity of exercise. At higher intensities or during very long-duration exercise, this does not seem to be the case. The mode of exercise does not seem to be a significant factor in altering cardiac cAMP concentration. Duration is more important than intensity in determining cAMP-PDE activity. Post-exercise increases in cAMP-PDE are very similar in trained animals, independent of duration and intensity of work. These increases are attenuated and less variable as compared with untrained animals. The activity of A-kinase seems to increase with exercise training. The extent of the increase in A-kinase activity is likely dependent on the duration (and perhaps the intensity) of training and is of greater magnitude than the changes in the other enzymes of the cAMP system.
综述了急性和慢性运动对3',5'-环磷酸腺苷（cAMP）浓度、腺苷酸环化酶活性、cAMP磷酸二酯酶（PDE）以及cAMP依赖性蛋白激酶（A激酶）活性的影响。在持续时间长达1小时的非常轻度至中度强度运动期间，心肌内的cAMP浓度与运动强度相关。在更高强度或非常长时间的运动期间，情况似乎并非如此。运动方式似乎不是改变心脏cAMP浓度的重要因素。在决定cAMP-PDE活性方面，持续时间比强度更重要。训练有素的动物运动后cAMP-PDE的增加非常相似，与工作的持续时间和强度无关。与未训练的动物相比，这些增加减弱且变异性较小。A激酶的活性似乎随着运动训练而增加。A激酶活性增加的程度可能取决于训练的持续时间（也许还有强度），并且比cAMP系统中其他酶的变化幅度更大。
