Preece N E, Amor S, Baker D, Gadian D G, O'Neill J K, Urenjak J
Royal College of Surgeons Unit of Biophysics, Institute of Child Health, London, United Kingdom.
Magn Reson Med. 1994 Dec;32(6):692-7. doi: 10.1002/mrm.1910320603.
In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Biozzi AB/H mouse, marked increases in the initially low levels of N-trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo-inositol during acute and again during chronic relapsing EAE. The ratio of N-acetyl-aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.
