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[使用PhastSystem设备检测脑脊液中寡克隆区带的诊断价值]

[Diagnostic value of oligoclonal band detection in cerebrospinal fluid using PhastSystem device].

作者信息

Zaborski J, Fiszer U, Kruszewska J, Korlak J, Poniatowska R, Członkowska A

机构信息

Klinika Chorób Naczyniowych Układu Nerwowego Instytutu Psychiatrii i Neurologii, Warszawie.

出版信息

Neurol Neurochir Pol. 1994 Nov-Dec;28(6):815-24.

PMID:7870255
Abstract

The study confirming the presence of oligoclonal IgG in cerebrospinal fluid by isoelectric focusing (IEF) with PhastSystem equipment was carried out in 68 patients with clinically definite MS, in 23 with clinically probable MS and in 23 with other neurological diseases. Other indicators intrathecal synthesis of IgG were olso marked. According to the results it was confirmed that the most sensitive method of detection of intrathecal synthesis of immunoglobulins is finding of the oligoclonal IgG. Using the PhastSystem evidently shorties the diagnostic process. The sensivity of the method equals that of MRI and both have similar clinical value.

摘要

通过使用PhastSystem设备的等电聚焦(IEF)来确认脑脊液中寡克隆IgG存在的研究,是在68例临床确诊的多发性硬化症患者、23例临床可能的多发性硬化症患者以及23例患有其他神经系统疾病的患者中进行的。鞘内IgG合成的其他指标也有记录。根据结果证实,检测免疫球蛋白鞘内合成最敏感的方法是发现寡克隆IgG。使用PhastSystem明显缩短了诊断过程。该方法的灵敏度与MRI相当,两者具有相似的临床价值。

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