Ershov A I, Tikhonov V A, Evstaf'ev Iu A, Sharunov S I, Grigaliunas A P, Rodina I N
Probl Tuberk. 1994(5):28-30.
Blood levels of cyclic nucleotides and their actions on central hemodynamics were studied in 129 patients with pulmonary tuberculosis. A direct correlation was established between heart rate, pulmonary artery systolic pressure and concentrations of cyclic adenosine monophosphate. Basing on this finding, the authors propose introduction of beta-adrenoblockers in hyperkinetic circulation tuberculous patients to prevent cor pulmonale. Administration of anapriline in tuberculous patients with compensated cor pulmonale and symptoms of sympathoadrenal hyperfunction improves the patients' condition, promotes a decrease in cardiac output, cardiac index, systolic pressure in the pulmonary artery. No side effects of the drug were reported.
对129例肺结核患者的循环核苷酸血药浓度及其对中心血流动力学的作用进行了研究。发现心率、肺动脉收缩压与环磷酸腺苷浓度之间存在直接相关性。基于这一发现，作者建议对有高动力循环的结核病患者使用β-肾上腺素能阻滞剂以预防肺心病。对有代偿性肺心病且伴有交感肾上腺功能亢进症状的结核病患者给予心得安可改善患者状况，促使心输出量、心脏指数及肺动脉收缩压降低。未报告该药物有副作用。
