Parellada E, Catafau A M, Bernardo M, Lomeña F, González-Monclús E, Setoain J
Department of Psychiatry, University of Barcelona, Spain.
Psychiatry Res. 1994 Sep;55(3):131-9. doi: 10.1016/0925-4927(94)90021-3.
Regional cerebral blood flow (rCBF) was measured with single photon emission computed tomography (SPECT) in six neuroleptic-naive, young, acute schizophrenic patients and six normal control subjects. We evaluated rCBF changes in prefrontal areas at rest and during a prefrontal activation task, the Wisconsin Card Sorting Test (WCST). Schizophrenic patients had significantly higher prefrontal blood flow than did control subjects during the resting conditions. During activation, the control group showed significant increases in prefrontal blood flow, whereas the schizophrenic group did not. These results suggest that at rest there is no evidence of hypofrontality, whereas hyperfrontality seems to be the most frequent pattern in our selected sample of young acute neuroleptic-naive schizophrenic patients. Furthermore, schizophrenic patients seem to be unable to increase prefrontal blood flow under conditions that challenge the prefrontal cortex.
我们采用单光子发射计算机断层扫描（SPECT）对6例未服用过抗精神病药物的年轻急性精神分裂症患者及6例正常对照者进行了局部脑血流（rCBF）测定。我们评估了静息状态下及在一项前额叶激活任务——威斯康星卡片分类测验（WCST）期间前额叶区域的rCBF变化。在静息状态下，精神分裂症患者的前额叶血流量显著高于对照组。在激活过程中，对照组前额叶血流量显著增加，而精神分裂症组则未增加。这些结果表明，静息时没有前额叶功能低下的证据，而在我们所选的未服用过抗精神病药物的年轻急性精神分裂症患者样本中，前额叶功能亢进似乎是最常见的模式。此外，精神分裂症患者在挑战前额叶皮质的条件下似乎无法增加前额叶血流量。
