Cross A J, Misra A, Sandilands A, Taylor M J, Green A R
Astra Neuroscience Research Unit, London, UK.
Psychopharmacology (Berl). 1993;111(1):96-8. doi: 10.1007/BF02257413.
Administration to mice of harmaline (100 mg/kg SC) resulted in a greater than two-fold increase in cyclic GMP in the cerebellum 15 min later. This response was inhibited by pretreatment 5 min before the harmaline with pentobarbital (ED50 6.5 mg/kg), chlormethiazole (ED50 10.4 mg/kg) and dizocilpine (ED50 0.5 mg/kg). Harmaline-induced tremor was inhibited by pentobarbital (ED50 30 mg/kg) and chlormethiazole (ED50 50 mg/kg) but not dizocilpine. The data demonstrate that the harmaline-induced tremor and cerebellar cyclic GMP rise are probably not associated. They also demonstrate that chlormethiazole is able to inhibit a biochemical response (the increase in cerebellar cyclic GMP) which results from increased glutamate function.
给小鼠皮下注射100毫克/千克的骆驼蓬碱，15分钟后其小脑内的环磷酸鸟苷（cGMP）增加了两倍多。在注射骆驼蓬碱前5分钟用戊巴比妥（半数有效量为6.5毫克/千克）、氯美噻唑（半数有效量为10.4毫克/千克）和地佐环平（半数有效量为0.5毫克/千克）进行预处理，可抑制这种反应。骆驼蓬碱诱发的震颤可被戊巴比妥（半数有效量为30毫克/千克）和氯美噻唑（半数有效量为50毫克/千克）抑制，但不能被地佐环平抑制。数据表明，骆驼蓬碱诱发的震颤和小脑环磷酸鸟苷升高可能没有关联。它们还表明，氯美噻唑能够抑制因谷氨酸功能增强而产生的生化反应（小脑环磷酸鸟苷增加）。
