嗜银性核仁组织区可能有助于慢性胰腺炎与胰腺导管腺癌之间的鉴别诊断。
Argyrophilic nucleolar organizer regions may help the differential diagnostic distinction between chronic pancreatitis and pancreatic ductal adenocarcinoma.
作者信息
Mäkinen K, Eskelinen M, Lipponen P, Pasanen P, Nuutinen P, Alhava E
机构信息
Dept. of Surgery, University of Kuopio, Finland.
出版信息
Scand J Gastroenterol. 1994 Nov;29(11):1029-33. doi: 10.3109/00365529409094881.
BACKGROUND
The aim of this study was to determine whether the number of argyrophilic nucleolar organizer regions (AgNORs) could be of diagnostic significance in differentiating between chronic pancreatitis and pancreatic ductal adenocarcinoma.
METHODS
The number of AgNORs was enumerated in biopsy specimens of normal pancreas, chronic pancreatitis, and pancreatic ductal adenocarcinoma.
RESULTS
The number of AgNORs was lower in patients with normal pancreas than in patients with chronic pancreatitis or pancreatic adenocarcinoma. In addition, the number of AgNORs was significantly lower in chronic pancreatitis than in pancreatic ductal adenocarcinoma (p < 0.001).
CONCLUSIONS
The diagnosis of pancreatic adenocarcinoma is usually clear. Difficulties can be encountered, however, in cases of chronic pancreatitis, specially when biopsy material is small. Our results suggest that the number of AgNORs may help in distinguishing between chronic pancreatitis and pancreatic ductal adenocarcinoma, especially in diagnostically difficult specimens.
背景
本研究的目的是确定嗜银核仁组织区（AgNORs）的数量在鉴别慢性胰腺炎和胰腺导管腺癌方面是否具有诊断意义。
方法
对正常胰腺、慢性胰腺炎和胰腺导管腺癌的活检标本中的AgNORs数量进行计数。
结果
正常胰腺患者的AgNORs数量低于慢性胰腺炎或胰腺腺癌患者。此外，慢性胰腺炎患者的AgNORs数量显著低于胰腺导管腺癌患者（p < 0.001）。
结论
胰腺腺癌的诊断通常较为明确。然而，在慢性胰腺炎病例中，尤其是活检材料较少时，可能会遇到困难。我们的结果表明，AgNORs的数量可能有助于区分慢性胰腺炎和胰腺导管腺癌，特别是在诊断困难的标本中。
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