[炎症性风湿性疾病患者长期使用甲氨蝶呤治疗时肢端结节病的发病率]
[Incidence of acral nodulosis with long-term methotrexate therapy in patients with inflammatory rheumatic diseases].
作者信息
Wagener P
机构信息
Rheumazentrum Hannover.
出版信息
Z Rheumatol. 1994 Nov-Dec;53(6):346-50.
The significance of acral nodulosis under methotrexate therapy is still controversial. Among patients with rheumatoid arthritis and methotrexate therapy this manifestation could be observed in 8/163 (5%). All cases were seropositive and already treated with other LAAD. Patients with other inflammatory rheumatic diseases under methotrexate therapy (n = 83) did not develop this nodulosis. The acral nodulosis is interpreted as a typical side-effect of methotrexate only in patients with rheumatoid arthritis. Histopathologically, these nodules do not differ from the typical rheumatoid nodule.
甲氨蝶呤治疗下出现肢端结节病的意义仍存在争议。在类风湿关节炎接受甲氨蝶呤治疗的患者中，163例中有8例（5%）出现了这种表现。所有病例均为血清阳性，且已接受其他慢作用抗风湿药治疗。接受甲氨蝶呤治疗的其他炎性风湿性疾病患者（n = 83）未出现这种结节病。肢端结节病仅在类风湿关节炎患者中被视为甲氨蝶呤的典型副作用。组织病理学上，这些结节与典型的类风湿结节并无差异。
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