Baron B W, Mick R, Baron J M
Department of Pathology, University of Chicago, IL 60637.
Acta Haematol. 1994;92(3):119-22. doi: 10.1159/000204199.
Between 1952 and 1992, we identified 117 African Americans with renal cell carcinoma (RCC) at the University of Chicago. Three of these had sickle cell disease (SS) and 11 had presumed sickle trait (AS). Based on genotype frequencies, these represented a 16.7-fold excess of SS patients (p < 0.0001), but the incidence of AS patients was as expected. In addition, the median age for the SS patients at presentation with RCC (36 years) was significantly less (p = 0.04) than for the AS patients (55 years). We have found no prior reports of SS in RCC patients and suggest that chronic renal injury from sickling and possible immunosuppressive effects of multiple red cell transfusions may be risk factors. We also suggest the need to be aware of the possibility of RCC in SS patients who may have hematuria solely related to sickling.
1952年至1992年间，我们在芝加哥大学确诊了117例患有肾细胞癌（RCC）的非裔美国人。其中3例患有镰状细胞病（SS），11例推测具有镰状细胞特征（AS）。根据基因型频率，SS患者的数量超出预期16.7倍（p < 0.0001），但AS患者的发病率与预期相符。此外，SS患者确诊RCC时的中位年龄（36岁）显著低于AS患者（55岁）（p = 0.04）。我们未发现此前有关于RCC患者中SS的报道，并认为镰状化引起的慢性肾损伤以及多次红细胞输血可能产生的免疫抑制作用可能是风险因素。我们还建议，对于可能仅有与镰状化相关血尿的SS患者，需要警惕其患RCC的可能性。
