Leblhuber F
Abteilung für Neurologisch-Psychiatrische Gerontologie, Landes-Nervenklinik Wagner-Jauregg, Linz.
Acta Med Austriaca. 1994;21(4):104-6.
Behavioral disturbances are a common complication in dementia. The underlying cause of this condition is mainly a disturbance of serotonin neurotransmission. In this paper the effect of citalopram on behavioral disturbances was studied in 20 patients with dementia. After 3 weeks of treatment improvement of the symptoms confusion and restlessness of the Gottfries-Brane-Steen Geriatric Scale was found (p < 0.05). These findings underline the effect of citalopram as emotional "stabilizer" in demented patients, as already described in earlier studies.
行为障碍是痴呆症常见的并发症。这种情况的根本原因主要是血清素神经传递紊乱。本文对20例痴呆患者研究了西酞普兰对行为障碍的影响。治疗3周后,发现Gottfries-Brane-Steen老年量表中的混乱和不安症状有所改善(p<0.05)。这些发现强调了西酞普兰作为痴呆患者情绪“稳定剂”的作用,正如早期研究所描述的那样。