米诺环素诱导的溶血性贫血。

Minocycline-induced hemolytic anemia.

作者信息

Kudoh T, Nagata N, Suzuki N, Nakata S, Chiba S, Takahashi T

机构信息

Department of Pediatrics, School of Medicine, Sapporo Medical University, Japan.

出版信息

Acta Paediatr Jpn. 1994 Dec;36(6):701-4. doi: 10.1111/j.1442-200x.1994.tb03274.x.

DOI:10.1111/j.1442-200x.1994.tb03274.x

PMID:7871987

Abstract

A case of drug-induced immune hemolytic anemia is described. A 2 year old boy exhibited sudden anemia and hemoglobinuria after administration of minocycline (MINO). The specific immunoglobulin G antibody against MINO was demonstrated in the patient's serum by western blotting. This is a rare example where anti-minocycline immune complex-mediated hemolysis was responsible for an intravascular hemolytic process.

摘要

描述了一例药物性免疫性溶血性贫血病例。一名2岁男孩在服用米诺环素（MINO）后出现突然贫血和血红蛋白尿。通过蛋白质印迹法在患者血清中检测到针对米诺环素的特异性免疫球蛋白G抗体。这是一个罕见的例子，其中抗米诺环素免疫复合物介导的溶血导致了血管内溶血过程。