Skre I, Onstad S, Edvardsen J, Torgersen S, Kringlen E
Department of Psychology, University of Tromsø, Norway.
Acta Psychiatr Scand. 1994 Nov;90(5):366-74. doi: 10.1111/j.1600-0447.1994.tb01608.x.
The prevalence of mental disorders in 76 first-degree relatives (parents and nontwin siblings) of 33 subjects with anxiety disorder was compared with the prevalence of mental disorders in 45 first-degree relatives of 20 subjects with mood disorder and 13 first-degree relatives of 6 subjects with psychoactive substance use disorder. All subjects were personally interviewed with the Structured Clinical Interview for DSM-III-R Axis I (SCID I). Interrater reliability was high for most diagnoses. Significantly more first-degree relatives of subjects with anxiety disorder had panic disorder and generalized anxiety disorder compared with relatives of probands with mood disorder. Significantly more female than male relatives of anxiety subjects suffered from anxiety disorders; there were no gender differences in the prevalence of anxiety disorders in relatives of mood and psychoactive substance use disorder (PSUD) subjects. The combination of anxiety and mood disorder was overrepresented in first-degree relatives of subjects with the same type of comorbidity. In relatives of subjects with mixed anxiety and psychoactive substance use disorder, but no mood disorder, there was an overrepresentation of PSUD; mainly alcohol abuse or dependence.
对33名焦虑症患者的76名一级亲属（父母和非双胞胎兄弟姐妹）的精神障碍患病率，与20名心境障碍患者的45名一级亲属以及6名精神活性物质使用障碍患者的13名一级亲属的精神障碍患病率进行了比较。所有受试者均接受了针对《精神疾病诊断与统计手册第三版修订本》轴I障碍的结构化临床访谈（SCID I）。大多数诊断的评分者间信度较高。与心境障碍先证者的亲属相比，焦虑症患者的一级亲属中患惊恐障碍和广泛性焦虑障碍的显著更多。焦虑症患者的女性亲属患焦虑症的显著多于男性亲属；心境障碍和精神活性物质使用障碍（PSUD）患者亲属中焦虑症患病率无性别差异。焦虑症和心境障碍的组合在患有相同类型共病的患者的一级亲属中比例过高。在患有混合性焦虑和精神活性物质使用障碍但无心境障碍的患者的亲属中，PSUD比例过高；主要是酒精滥用或依赖。
