Savica V, Costantino G, Monardo P, Bellinghieri G
Chair of Nephrology, School of Medicine, University of Messina, Italy.
Am J Nephrol. 1995;15(1):10-4. doi: 10.1159/000168795.
This paper reports a study on the treatment of predialysis patients with recombinant human erythropoietin (r-HuEPO). The haematocrit, haemoglobin, reticulocyte and platelet values as well as creatinine and creatinine clearance evaluated by standard and radio-isotopic methods before, during and after r-HuEPO treatment were determined. The slope of the inverse creatinine versus time curves was studied too. The authors did not observe any variation of the renal function parameters during and after study and suggest their protocol of r-HuEPO administration for predialysis patients.
本文报道了一项关于重组人促红细胞生成素（r-HuEPO）治疗透析前患者的研究。测定了r-HuEPO治疗前、治疗期间和治疗后的血细胞比容、血红蛋白、网织红细胞和血小板值，以及通过标准方法和放射性同位素方法评估的肌酐和肌酐清除率。还研究了肌酐与时间曲线倒数的斜率。作者在研究期间和研究后未观察到肾功能参数有任何变化，并提出了他们针对透析前患者的r-HuEPO给药方案。
