Steib A
Service d'Anesthésie-Réanimation Chirurgicale, Hôpital de Hautepierre, Strasbourg.
Ann Fr Anesth Reanim. 1994;13(4):471-5. doi: 10.1016/s0750-7658(05)80674-4.
Concerning the pharmacokinetic or pharmacodynamic interactions, the following is recommended: Use smaller doses of alfentanil when the latter is combined with propofol, because of a higher risk of ventilatory depression. Decrease doses of each agent whenever propofol is combined with thiopentone or midazolam to induce anaesthesia. The prophylactic or therapeutic use of atropine is indicated when propofol is associated with agents reducing heart rate. Prefer propofol to induce anaesthesia for eye surgery, if suxamethonium is required. In the absence of sufficient data, propofol should be administered with care in patients taking cardiovascular medication (risk of hypotension) or cyclosporine (enhanced toxicity).
关于药代动力学或药效学相互作用，建议如下：当阿芬太尼与丙泊酚合用时，应使用较小剂量的阿芬太尼，因为呼吸抑制风险较高。当丙泊酚与硫喷妥钠或咪达唑仑联合用于诱导麻醉时，应减少每种药物的剂量。当丙泊酚与降低心率的药物联用时，需使用阿托品进行预防或治疗。如果需要琥珀酰胆碱，在眼科手术中首选丙泊酚诱导麻醉。在缺乏足够数据的情况下，服用心血管药物（有低血压风险）或环孢素（毒性增强）的患者应谨慎使用丙泊酚。
