Naik H R, Lehr J E, Pienta K J
Division of Hematology and Oncology, Wayne State University School of Medicine, Detroit, MI 48201.
Anticancer Res. 1994 Nov-Dec;14(6B):2617-9.
Hormone refractory prostate cancer remains an incurable disease. Newer agents with more activity are required. Genistein is a flavone compound with anti-tumor activity against various tumor systems in vitro. This study is undertaken to assess the efficacy of genistein against hormone refractory prostate cancer. In vitro, genistein appears to be cytotoxic to both the rat prostate cancer cell line MAT-LyLu and the human prostate adenocarcinoma cell line, PC-3. In vivo, however, genistein failed to significantly inhibit the growth of subcutaneously implanted MAT-LyLu cells. More information regarding the pharmacokinetics and bio-availability of genistein is needed to determine if this is an active agent in human metastatic prostate cancer.
激素难治性前列腺癌仍然是一种无法治愈的疾病。需要更具活性的新型药物。染料木黄酮是一种黄酮类化合物，在体外对各种肿瘤系统具有抗肿瘤活性。本研究旨在评估染料木黄酮对激素难治性前列腺癌的疗效。在体外，染料木黄酮似乎对大鼠前列腺癌细胞系MAT-LyLu和人前列腺腺癌细胞系PC-3均具有细胞毒性。然而，在体内，染料木黄酮未能显著抑制皮下植入的MAT-LyLu细胞的生长。需要更多关于染料木黄酮的药代动力学和生物利用度的信息，以确定它是否是人类转移性前列腺癌的有效药物。
