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Production and characterization of monoclonal antibodies against a human ovarian teratocarcinoma cell line.

作者信息

Lemieux P, Pagé M

机构信息

Department of Biochemistry, Faculty of Medicine, Université Laval Sainte-Foy, Québec, Canada.

出版信息

Anticancer Res. 1994 Nov-Dec;14(6B):2709-15.

PMID:7872706
Abstract

Nine monoclonal antibodies (MAbs) of a total of 125 clones selected by an enzyme immunoassay (ELISA) were produced against a human ovarian teratocarcinoma cell line. Within the panel, one antibody (4E3) has shown a close reactivity to OC-125. However, the antigen recognized by 4E3 was found to be different from the CA-125 antigen. The cell surface antigen recognized by 4E3 has a molecular weight over 2 x 10(6) Da and is highly glycosylated as shown by the periodic acid/Schiff reagent.

摘要

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