β-内酰胺-β-内酰胺酶抑制剂组合对产TEM-26型肺炎克雷伯菌菌株的体内疗效。
In vivo efficacies of beta-lactam-beta-lactamase inhibitor combinations against a TEM-26-producing strain of Klebsiella pneumoniae.
作者信息
Rice L B, Carias L L, Shlaes D M
机构信息
Medical Research Service, Department of Veterans Affairs Medical Center, Cleveland, OH 44106.
出版信息
Antimicrob Agents Chemother. 1994 Nov;38(11):2663-4. doi: 10.1128/AAC.38.11.2663.
Abstract
We examined the efficacies of the beta-lactam-beta-lactamase inhibitor combinations ampicillin-sulbactam and piperacillin-tazobactam in the treatment of intra-abdominal abscesses caused by a TEM-26-producing strain of Klebsiella pneumoniae. At lower doses, both combinations reduced abscess colony counts by more than 3 log10 CFU/g from that of untreated controls, but treatment with these drugs was inferior to treatment with imipenem. Increasing the doses of the combinations resulted in a further decrease in abscess CFU to a level where both were similar to imipenem in efficacy. These results suggest that the beta-lactam-beta-lactamase inhibitor combinations ampicillin-sulbactam and piperacillin-tazobactam may be viable alternatives for the treatment of serious infections caused by susceptible extended-spectrum beta-lactamase-producing strains of K. pneumoniae.
摘要
我们研究了β-内酰胺-β-内酰胺酶抑制剂组合氨苄西林-舒巴坦和哌拉西林-他唑巴坦治疗由产TEM-26型肺炎克雷伯菌引起的腹腔内脓肿的疗效。在较低剂量下，两种组合均使脓肿菌落计数比未治疗的对照组减少超过3个log10 CFU/g，但使用这些药物治疗不如亚胺培南治疗。增加组合剂量导致脓肿CFU进一步降低至两者疗效与亚胺培南相似的水平。这些结果表明，β-内酰胺-β-内酰胺酶抑制剂组合氨苄西林-舒巴坦和哌拉西林-他唑巴坦可能是治疗由敏感的产超广谱β-内酰胺酶肺炎克雷伯菌菌株引起的严重感染的可行替代方案。
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