New trends in aminoglycoside dosing.

Aminoglycosides are narrow spectrum antibiotics used primarily for serious aerobic gram-negative infections. The concept of once daily dosing to reduce aminoglycoside toxicity while ensuring adequate serum concentrations has many advantages. The properties of PAE and concentration dependent bactericidal activity are especially valuable. Comparison of single daily dosing to traditional thrice daily dosing has proven to be of equal efficacy in clinical trials. In addition to the projected reduction of ototoxicity and nephrotoxicity, once daily dosing would guarantee peak serum concentrations in the therapeutic range, provide easier outpatient administration, decrease personnel time, and reduce costs.