Fukiage T, Chikamatsu K, Matsuoka H, Murakami H, Eura M, Masuyama K, Ishikawa T
Department of Otolaryngology, Kumamoto University School of Medicine, Japan.
Auris Nasus Larynx. 1994;21(3):163-72. doi: 10.1016/s0385-8146(12)80139-8.
A cancer cell line named FS-1 was established from maxillary cancer of which histological diagnosis was well differentiated squamous cell carcinoma (SCC). The HLA class I typing showed that FS-1 expressed the same HLA class I antigens as those of the host lymphocytes. The chromosome analysis and nuclear DNA contents suggested that FS-1 was not a normal human cell. FS-1 is characteristic of SCC in that it grows adhesively on the surface of a culture flask. The structure of tumor tissue obtained from FS-1-transplanted nude mice is very much like the original tissue of SCC. The SCC-antigen was determined in the culture supernatant of FS-1. Autologous tumor killing activity was induced from peripheral blood lymphocytes of some patients suffering from head and neck SCC after mixed lymphocyte tumor culture with FS-1. Thus, FS-1 can serve as a useful allogeneic stimulator of SCC for induction of autologous tumor killing activity.
一种名为FS-1的癌细胞系是从组织学诊断为高分化鳞状细胞癌（SCC）的上颌癌中建立的。HLA I类分型显示，FS-1表达的HLA I类抗原与宿主淋巴细胞相同。染色体分析和核DNA含量表明，FS-1不是正常人类细胞。FS-1具有SCC的特征，即它在培养瓶表面粘附生长。从移植了FS-1的裸鼠获得的肿瘤组织结构与SCC的原始组织非常相似。在FS-1的培养上清液中检测到了SCC抗原。一些头颈部SCC患者的外周血淋巴细胞在与FS-1进行混合淋巴细胞肿瘤培养后，诱导出了自体肿瘤杀伤活性。因此，FS-1可作为SCC有用的异基因刺激物，用于诱导自体肿瘤杀伤活性。
