Martin G, Meyer H
Institut für Veterinärmedizin (Robert von Ostertag-Institut), Bereich Jena.
Berl Munch Tierarztl Wochenschr. 1994 Nov;107(11):382-4.
Anticoccidial agents are obligatory feed additives during several rearing periods of poultry. The success of an oral immunization of young chicken with Salmonella live vaccines depends on the insensitivity of the vaccine strain against such anticoccidial agents because the vaccination success depends on the survival of the vaccine strain in the gut of the chick and the temporary colonization of lymphatic tissue. We investigated the in vitro sensitivity of the vaccine strain in the S. typhimurium live vaccine "Zoosaloral H" registered for the vaccination of poultry in Germany in connection with often used anticoccidial agents (Diclazuril, Monensin, Narasin and Salinomycin). No differences in growth and survival between the samples containing and lacking anticoccidial agents were found even by using double amounts of the permitted concentration of the anticoccidial agents. No negative effects of the tested anticoccidial agents on Salmonella being used as oral live vaccines in poultry should be expected.
抗球虫药是家禽几个饲养阶段必不可少的饲料添加剂。用沙门氏菌活疫苗对幼鸡进行口服免疫的成功与否取决于疫苗菌株对此类抗球虫药的不敏感性，因为疫苗接种的成功取决于疫苗菌株在雏鸡肠道内的存活以及在淋巴组织中的短暂定植。我们研究了德国注册用于家禽疫苗接种的鼠伤寒沙门氏菌活疫苗“Zoosaloral H”中的疫苗菌株与常用抗球虫药（地克珠利、莫能菌素、那拉菌素和盐霉素）的体外敏感性。即使使用双倍允许浓度的抗球虫药，在含有和不含抗球虫药的样品之间也未发现生长和存活方面的差异。预计所测试的抗球虫药对用作家禽口服活疫苗的沙门氏菌没有负面影响。
