Altieri P I, González R, de Mello W, Escobales N
Departamento de Medicina, Farmacología, Fisiología, Universidad de Investigación Cardiovascular del Recinto de Ciencias Médicas de la Universidad de Puerto Rico.
Rev Port Cardiol. 1994 Dec;13(12):913-7, 892.
The present study shows that enalapril prevents the excessive remodeling of the left ventricle after acute myocardial infarction. This randomized and double blind clinical study analysed 50 patients with an inferior myocardial infarction. The effect of enalapril was evaluated through cardiac volumes, ejection fraction, neurohormonal levels and incidence of the left ventricle disfunction after acute myocardial infarction. The patients treated with enalapril showed a significant reduction on the values of nor-epinefrine, angiotensine II, natriuretic hormone and vasopressine, four weeks after initiation of treatment. The ejection fraction and the level of the wall movement was more favourable, four weeks after infarction, in the group treated with enalapril. The incidence of congestive heart failure and arrhythmias was lower in the group treated with enalapril. So, we conclude that enalapril is a drug that prevents the excessive remodelling of the left ventricle after an acute myocardial infarction.
本研究表明，依那普利可预防急性心肌梗死后左心室的过度重塑。这项随机双盲临床研究分析了50例下壁心肌梗死患者。通过心脏容积、射血分数、神经激素水平以及急性心肌梗死后左心室功能障碍的发生率来评估依那普利的效果。接受依那普利治疗的患者在治疗开始四周后，去甲肾上腺素、血管紧张素II、利钠激素和加压素的值显著降低。梗死四周后，依那普利治疗组的射血分数和室壁运动水平更理想。依那普利治疗组充血性心力衰竭和心律失常的发生率较低。因此，我们得出结论，依那普利是一种可预防急性心肌梗死后左心室过度重塑的药物。
