Gong Z, Hew C L
Research Institute, Hospital for Sick Children, University of Toronto, Canada.
Biochim Biophys Acta. 1995 Feb 21;1260(3):349-54. doi: 10.1016/0167-4781(94)00228-u.
Several novel cDNA clones have been isolated from a chinook salmon pituitary cDNA library. Sequence analysis of these clones indicates that they are closely related to the rat LIM domain homeobox gene, isl-1. Due to differential splicing, several of the clones encode truncated polypeptides containing a complete copy of the LIM domain without the homeodomain and C-terminal activation domain. The roles of these truncated polypeptides are discussed.
从奇努克鲑鱼垂体cDNA文库中分离出了几个新的cDNA克隆。对这些克隆的序列分析表明,它们与大鼠LIM结构域同源框基因isl-1密切相关。由于可变剪接,其中几个克隆编码截短的多肽,这些多肽包含一个完整的LIM结构域拷贝,但没有同源结构域和C端激活结构域。文中讨论了这些截短多肽的作用。