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[再灌注期间进入细胞的钙离子在再灌注性心律失常起始和维持机制中的作用]

[The role of Ca2+, entering the cell during reperfusion, in the mechanism of initiation and maintenance of reperfusion arrhythmias].

作者信息

Burashnikov A Iu, Medvinskiĭ A B

出版信息

Biofizika. 1994 Nov-Dec;39(6):1058-62.

PMID:7873628
Abstract

The role of calcium ions entering cells upon reperfusion of ischemic myocardium for reperfusion arrhythmias has been investigated on the model of isolated rat right ventricle perfused through coronary artery. Manipulation by concentration of calcium ions in the reperfusion solution demonstrates that calcium ions entering cells upon reperfusion do not play a major role in the initiation of reperfusion extrasystoles and tachycardias, but have a significant influence on the maintenance of tachycardias. Multielectrode mapping revealed a focal source as the mechanism underlying reperfusion arrhythmias at low concentration or in the absence of calcium ions in the reperfusion solution.

摘要

在通过冠状动脉灌注的离体大鼠右心室模型上，研究了缺血心肌再灌注时进入细胞的钙离子在再灌注心律失常中的作用。通过改变再灌注溶液中钙离子的浓度进行操作表明，再灌注时进入细胞的钙离子在再灌注期外收缩和心动过速的起始中不起主要作用，但对心动过速的维持有显著影响。多电极标测显示，在再灌注溶液中钙离子浓度较低或不存在钙离子的情况下，局灶性起源是再灌注心律失常的潜在机制。

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Biofizika. 1994 Nov-Dec;39(6):1058-62.
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