Webb D J
University Department of Medicine, Western General Hospital, Edinburgh, UK.
J Vasc Res. 1995 Jan-Feb;32(1):2-15. doi: 10.1159/000159072.
Forearm plethysmography coupled with brachial artery drug administration and the Aellig technique in hand veins coupled with local venous drug administration are both extremely powerful tools, now widely available to the clinical pharmacologist. These techniques allow precise assessment of drug effects on vascular smooth muscle in vivo, without the confounding influences of drug effects on other organs or activation of neurohumoral reflexes. These local techniques allow the direct study of human vascular physiology, pharmacology, and pathophysiology in vivo in humans. In addition, they can form an important part of the early clinical development programme for new cardiovascular drugs, including drugs affecting the renin-angiotensin system and the sympathetic nervous system, as well as the novel agents arising from research on the vascular endothelium. Given the power of these techniques, it is important to consider where studies in patient volunteers might answer particular questions better than experiments in animal models of disease.
前臂体积描记法结合肱动脉给药，以及手部静脉的阿埃利希技术结合局部静脉给药，都是极为强大的工具，临床药理学家现在广泛可用。这些技术能够在体内精确评估药物对血管平滑肌的作用，而不受药物对其他器官的作用或神经体液反射激活的混杂影响。这些局部技术允许在人体体内直接研究人类血管生理学、药理学和病理生理学。此外，它们可以成为新型心血管药物早期临床开发计划的重要组成部分，这些药物包括影响肾素-血管紧张素系统和交感神经系统的药物，以及血管内皮研究产生的新型药物。鉴于这些技术的强大功能，重要的是要考虑在哪些方面，患者志愿者研究可能比疾病动物模型实验能更好地回答特定问题。
