通过荧光原位杂交将人类TATA框结合蛋白（TBP）基因直接定位到6q27。
Direct mapping of the human TATA box-binding protein (TBP) gene to 6q27 by fluorescence in situ hybridization.
作者信息
Saito F, Yamamoto T, Horikoshi M, Ikeuchi T
机构信息
Department of Cytogenetics, Tokyo Medical and Dental University, Japan.
出版信息
Jpn J Hum Genet. 1994 Dec;39(4):421-5. doi: 10.1007/BF01892387.
TBP (TATA box-binding protein) participates in the expression of eukaryotic genes transcribed by RNA polymerases I, II, and III. Molecular cloning of human TBP revealed that the N-terminal region contains a polymorphic (CAG)n repeat. We report here the direct localization of human TBP gene to chromosome 6q2705-->qter region by fluorescence in situ hybridization, using the cDNA clone with or without the (CAG)n repeat as a probe.
TBP（TATA盒结合蛋白）参与由RNA聚合酶I、II和III转录的真核基因的表达。人类TBP的分子克隆显示其N端区域含有一个多态性的（CAG）n重复序列。我们在此报告，通过荧光原位杂交，利用带有或不带有（CAG）n重复序列的cDNA克隆作为探针，将人类TBP基因直接定位到染色体6q27.05→qter区域。
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