Kato N, Hirano T, Takeda K, Nakagawa T, Mizumoto T, Yuasa H, Shimizu Y
Department of Radiology, Mie University, Japan.
J Vasc Interv Radiol. 1994 Nov-Dec;5(6):805-12. doi: 10.1016/s1051-0443(94)71610-9.
The authors developed a percutaneous endoprosthesis for treatment of aortic dissections. The device is a Gianturco stent wrapped with Dacron or nylon mesh. Effectiveness of the covered stent versus a bare stent was compared in the treatment of acute aortic dissection.
Experimental aortic dissections were created in 10 mongrel dogs. Occlusion of intimal tears was attempted with covered stents in five dogs (group 1) and with bare stents in the remaining five dogs (group 2).
In group 1, entry tears were obliterated within 1 day (n = 3) or 1 week (n = 2) after stent placement and false lumina were thrombosed within 1 week (n = 3) or 1 month (n = 2). In group 2, entry tears and false lumina remained patent. Histologic specimens showed that the covered stents were entirely covered with smooth neointima.
This endoprosthesis offers an alternative to surgical treatment for dissections of the descending aorta.
作者研发了一种用于治疗主动脉夹层的经皮内置假体。该装置是一种包裹有涤纶或尼龙网的朱安特科支架。在治疗急性主动脉夹层时,对覆膜支架与裸支架的有效性进行了比较。
在10只杂种犬身上制造实验性主动脉夹层。5只犬(第1组)尝试用覆膜支架闭塞内膜破口,其余5只犬(第2组)用裸支架。
在第1组中,置入支架后1天内(n = 3)或1周内(n = 2)入口破口闭塞,假腔在1周内(n = 3)或1个月内(n = 2)形成血栓。在第2组中,入口破口和假腔保持通畅。组织学标本显示,覆膜支架完全被光滑的新生内膜覆盖。
这种内置假体为降主动脉夹层的手术治疗提供了一种替代方法。