铜绿假单胞菌半乳糖特异性凝集素PA-I与糖鞘脂及其他糖缀合物的结合。
Binding of the galactose-specific Pseudomonas aeruginosa lectin, PA-I, to glycosphingolipids and other glycoconjugates.
作者信息
Lanne B, Cîopraga J, Bergström J, Motas C, Karlsson K A
机构信息
Department of Medical Biochemistry, Göteborg University, Sweden.
出版信息
Glycoconj J. 1994 Aug;11(4):292-8. doi: 10.1007/BF00731201.
The carbohydrate-binding specificity of Pseudomonas aeruginosa lectin I (PA-I) in iodinated or biotinylated form was studied. A large number of glycosphingolipids, as well as some glycoproteins and neoglycoproteins were used as ligands. Also, inhibition by free saccharides of PA-I binding to glycosphingolipids was tested. It was found that the lectin binds most strongly to terminal and nonsubstituted Gal alpha 3Gal- or Gal alpha 4Gal-structures.
对碘化或生物素化形式的铜绿假单胞菌凝集素I（PA-I）的碳水化合物结合特异性进行了研究。大量糖鞘脂以及一些糖蛋白和新糖蛋白被用作配体。此外，还测试了游离糖类对PA-I与糖鞘脂结合的抑制作用。发现该凝集素与末端且未被取代的Galα3Gal-或Galα4Gal-结构结合最为紧密。
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