Olubadewo J O, Wingard M, Washington B, Tsai C S, Robinson T J, Ochillo R F
Laboratory of Pharmacology, Xavier University of Louisiana, New Orleans 70125.
Cell Mol Biol (Noisy-le-grand). 1994 Dec;40(8):1201-6.
In order to investigate the effects of transportation stress on metabolic activities, we measured the changes in plasma lipoprotein and catecholamine levels in those rats that had just arrived in our Animal Facility and age-matched rats which had acclimatized in the Facility for at least 21 days. The acclimatized rats were considered as control, and the values from the newly arrived rats was done within 4-6 days of their arrival in the Facility. The cholesterol levels in very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) were higher (71-84%) than the control levels. Also, the stressed animals had higher levels of norepinephrine (4.5-fold) and epinephrine (3-fold) than the control levels. However, dopamine levels was 34-fold lower than that of control. On the basis of the data, we concluded that the change in plasma levels of lipoprotein and catecholamines in response to the transportation stress is significant and may require at least three weeks after the transportation to establish a stable baseline for investigations in which the plasma levels of lipoproteins and catecholamines is a critical factor.
为了研究运输应激对代谢活动的影响，我们测量了刚抵达我们动物设施的大鼠以及在该设施中适应了至少21天的年龄匹配大鼠的血浆脂蛋白和儿茶酚胺水平的变化。适应环境的大鼠被视为对照，新抵达大鼠的值在其抵达设施后的4 - 6天内测定。极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）中的胆固醇水平比对照水平高（71 - 84%）。此外，应激动物的去甲肾上腺素水平（4.5倍）和肾上腺素水平（3倍）高于对照水平。然而，多巴胺水平比对照低34倍。基于这些数据，我们得出结论，运输应激引起的血浆脂蛋白和儿茶酚胺水平变化显著，并且可能需要运输后至少三周才能建立一个稳定的基线，以便在血浆脂蛋白和儿茶酚胺水平是关键因素的研究中使用。
