Kasimtsev A A, Nikolaev V G
Morfologiia. 1993 Nov-Dec;105(11-12):82-6.
Changes of the connective tissue structures, appearing during all postnatal ontogenesis stages were studied in 147 human lung specimens of different age groups (from newborns up to 82-year-olds). Qualitative and quantitative composition of connective tissue structures changes with the age which leads to the lateral aggregation of the fibers and growth of the general mass of the connective tissue. Heterochronia of the age variability manifestations in different regions of the lung framework was demonstrated. The original age transformations of connective tissue structures are characteristic for the basal lung regions. With the exception of perivasal connective tissue, similar changes in the region of the lung apexes appear 3-5 years later. This gives an opportunity to distinguish three anatomic zones in the lungs in an apico-basal direction, characterising the local nature of the age changes manifestations.
在147份不同年龄组(从新生儿到82岁)的人类肺标本中,研究了出生后各个发育阶段出现的结缔组织结构变化。结缔组织结构的定性和定量组成随年龄而变化,这导致纤维横向聚集和结缔组织总体质量增加。证明了肺框架不同区域年龄变异性表现的异时性。结缔组织结构的原始年龄变化是肺底部区域的特征。除血管周围结缔组织外,肺尖区域的类似变化在3 - 5年后出现。这使得有机会在肺中从尖部到基部方向区分三个解剖区域,表征年龄变化表现的局部性质。