Hogan D B, Thierer D E, Ebly E M, Parhad I M
Department of Medicine, University of Calgary, Alberta, Canada.
Can J Neurol Sci. 1994 Nov;21(4):331-8. doi: 10.1017/s0317167100040919.
Five hundred and fifty-three patients were referred to a Canadian dementia clinic for standardized evaluation. The majority (83.5%) had a dementia with Alzheimer's disease (AD) accounting for 89% of dementias. Patients with probable AD who were followed for five years had variable rates of progression, increased mortality (37.1%, 2.5 times the expected rate) and a high rate of institutionalization (79%). Simple demographic (age) and social factors (marital status) were strong predictors for institutionalization. It was extremely difficult at presentation to predict the rate of progression. The prevalence of AD in autopsied cases was 62.5%. Clinic patients were younger, had milder dementias, and were more likely to have AD than patients identified in the course of a contemporaneous population-based dementia prevalence study.
553名患者被转至一家加拿大痴呆症诊所进行标准化评估。大多数患者（83.5%）患有痴呆症，其中阿尔茨海默病（AD）占痴呆症患者的89%。对可能患有AD的患者进行了为期五年的随访，其病情进展速度各异，死亡率增加（37.1%，是预期死亡率的2.5倍），且入住机构的比例很高（79%）。简单的人口统计学因素（年龄）和社会因素（婚姻状况）是入住机构的有力预测因素。在就诊时极难预测病情进展速度。尸检病例中AD的患病率为62.5%。与同期基于人群的痴呆症患病率研究中确诊的患者相比，诊所患者更年轻，痴呆症状更轻，且更有可能患有AD。
